Varicocele

Causes of sperm DNA fragmentation

Varicocele occurs in 19 to 41% of infertile men and is considered the most common cause of male infertility. The exact mechanisms by which varicocele affects male fertility are still unknown. Recent data indicate a negative impact of increased DNA damage on male fertility potential.


Clinical Study for Varicocele

Zini showed a decrease in %DFI after varicocele surgery. Hum Reprod. 2005.20:1018-21

Can Sperm DNA Fragmentation Determine the Need for a Varicocelectomy?

Effect of microsurgical varicocelectomy on telomere length, DNA fragmentation and sperm
parameters Sandra Lara- Cerrillo et al (2020)

Below is an example of a patient in whom sperm DNA fragmentation decreased after varicocele repair:

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